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One newsletter, three audiences, each receiving content written for them. This guide uses scientists, pharmaceutical professionals, and academics as the example groups. The same pattern works for any segmented send.
Before you start. You need a verified sending domain and contacts in Brew with a field you can segment on, like a custom “Profession” field. See Add Contacts.
Every marketing recipient must have opted in to hear from you. Importing or syncing contact data into Brew is not permission to email it. See What You Can Send.

1. Generate the Layout

Open Emails in the sidebar and start a prompt in the chat. You have two options: Option A: layout first, content second. Generate a base layout with placeholder content, then apply your real content in a follow-up prompt.
“Create a newsletter with a hero section, three content preview sections with placeholder text, and dummy images. Clean, editorial layout.”
Then follow up with:
“Apply this content to the layout: [paste your links and descriptions]”
Option B: layout and content in one prompt. Paste your content directly and let Brew build the layout around it.
“Create a newsletter with sections that align to these links for a scientific audience: [blog link + description], [news link + description], [webinar link + description], [event link + description].”
Option A gives you a layout to review before committing to content. Option B is faster if your content is ready. Brew applies email best practices automatically: hierarchy, CTA placement, image balance, and footer structure. You don’t need to specify them.

2. Refine the Email

Once the first version is on the canvas, adjust it using chat or the built-in editor:
  • Fewer images. “Remove two of the images and make it more text-forward.”
  • Different images. Click into any image block and upload a replacement directly.
  • Style changes. “Switch to rounded borders throughout” or “Make the buttons outlined instead of filled.”
  • Dark mode version. “Create a dark mode variant of this email.” Brew generates it as a separate email on the canvas so you can compare both.

3. Create the Three Group Variants

With your base email on the canvas, generate a version for each audience group in one prompt:
“Create three versions of this email: one for scientists, one for pharmaceutical professionals, and one for academics. Keep the layout identical but swap in the relevant links and adjust the intro copy to speak directly to each group.”
All three appear on the canvas. Click into each one to review and fine-tune individually.

4. Set Up Your Audience Segments

Go to Audience in the sidebar. For each group, create a saved segment using filters:
  1. Click + Filter and select the contact field that identifies the group (for example, a custom field like “Profession” or “Membership”).
  2. Set the operator (for example, contains) and enter the value (for example, scientist). The table updates as you type and shows a count like “16 of 50 contacts”.
  3. Click Create new audience in the bar at the bottom of the screen, and name it (for example, Scientists).
Repeat for each group. You should have three saved audiences before sending:
  • Scientists
  • Pharmaceutical professionals
  • Academics
Your saved audiences appear in the audience switcher at the top of the Audience page. See Create Audiences for more on filtering options.

5. Send Each Variant to Its Group

Go back to the canvas. For each of the three email variants:
  1. Click Send in the toolbar.
  2. Set the subject line and preview text.
  3. Select the matching audience segment on the right.
  4. Confirm and send.
Each group receives only the version written for them. Sending right away is the default. Send Options also covers scheduling, intelligent send (each contact’s likeliest hour, within 24 hours), and gradual send (batches that grow over hours or days). For a weekly newsletter, intelligent send is the one worth trying. The issue lands when your readers check mail, not when you happened to click.

6. Repeat Each Week

When it’s time for the next issue, select any sent email on the canvas. Bring it into chat with Add to chat. Then drop in your new content:
“Update this newsletter with this week’s content: [new blog link], [new webinar], [new event]. Keep the layout and tone the same.”
Brew updates the email with the new content and preserves the structure. Generate the three group variants again, and send.

From an Agent or Code

Over MCP:
  • create_email generates the layout and edit_email refines it. Make each group version with its own create_email call, so each has its own emailId.
  • create_audience (or POST /v1/audiences) saves each segment from the same filters you’d click.
  • send_email with the variant’s emailId, a subject, a verified marketing domainId, the matching audienceId, and an idempotency_key sends it. Over the API that is POST /v1/sends, with scheduledAt to send later.
On OAuth and organization connections a send to an audience returns a confirmation request with the recipient count first. Repeat the call with confirmed: true and the returned confirmation_id after you approve. See Confirmation.

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